| 초록 |
Gene therapy to treat the genetic disease like cancer, restenosis has lot of importance in the field of biomedical science. Successful delivery of gene to the target site without side effects has been the aim to many researchers for more than a decade. Delivered gene has to be expressed efficiently in the target site, which is another area of concern. In order to overcome the drawbacks, cationic polymers have been employed to aid in the delivery of genes. But the cationic polymers were not degradable and its toxicity was an issue. In order to solve the issue, we employed the cationic polymer with modifications to deliver the genes. Modifications include polyethylene glycol attachment, introduction of disulfide bond and sorbitol group to the cationic polymer along with the degradable esters. Once these modifications were done the gene delivery was efficient without compromising the bio-compatibility. |
