| 초록 |
Recently, DNA has been widely used as nano-materials due to its superb molecular recognition ability. However, DNA has little attractive characters as materials. If non-natural molecules are available as pseudo pairs, we can endow DNA with a wide variety of functions. We have developed pseudo base pairs by incorporating non-natural molecules into DNA through acyclic D-threoninol linker. For example, pairs of azobenzene derivatives strongly stabilized DNA duplex when they are introduced into DNA. In addition, these pairs showed high orthogonality to natural base pairs. Thus, azobenzene derivatives worked as a pseudo base pair although their chemical structures are much different from natural base-pairs. We have developed functional molecules into DNA as pseudo base pairs by using this design. In the presentation, I will introduce molecular designs and functions of several pseudo base pairs we have developed. |
