| 초록 |
Heparin is best known for its anticoagulant properties, and also interacts with various proteins that have heparin-binding domains. So, heparin containing systems have been developed for the sustained release of proteins. In this study, We synthesize heparin conjugated pH/thermo responsive poly(β-amino ester urethane) multiblock copolymers for sustain release. The aqueous solution of the conjugate exhibits pH/temperature dependent sol-gel phase transitions that can be turned by changing solution concentration and heparin composition. The gel window well covers the physiological condition. The release profile of Human Growth Hormone(hGH), as a model protein, show that the conjugate hydrogel is able to effectively reduce the burst effect, in vivo, and maintain the sustained release of hGH over 3 weeks in the in vitro and in vivo experiments. Such conjugate hydrogel can be considered as a potential candidate for long-term delivery of proteins. |
