| 학회 | 한국공업화학회 |
| 학술대회 | 2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 | 19권 1호 |
| 발표분야 | 정밀화학_포스터 |
| 제목 | Practical production of acetaminophen via Cu-catalyzed reactions |
| 초록 | Acetaminophen is a common over-the-counter analgesic for minor pains, such as headaches and is also prescribed as an antipyretic. In spite of its extensive medical applications, any of the developed regioselective process has not been replaced the conventional process that contains nitration of phenol and purification of the desired p-regioisomer. Herein, a potent industrial process for acetaminophen is presented from p-dihalobenzenes via two Cu-catalyzed reactions. Each of the reactions proceeds to introduce the N-acetylamido and the hydroxyl functional groups without the use of the strong acids (HNO3, H2SO4) in the conventional process. The new Cu-catalyzed process regioselectively affords N-acetyl-p-aminophenol in more than 65% overall yields. |
| 저자 | 서영란, 김영규, 서상원, 김중원 |
| 소속 | 서울대 |
| 키워드 | acetaminophen; copper catalyzed reactions |
