| 초록 |
Nitric oxide(NO) is a signaling molecule that plays an important role in many physiological processes such as immune response, vascular regulation and neuronal signaling. So there have been many studies for exogenous NO delivery systems in biomedical treatments. However, NO is a free radical gas which has very short half-life, resulting in limited bioavailability of NO. For an effective delivery of NO, release profile control is the most indispensable in NO delivery systems. In this study, we developed NO donor loaded Poly(lactic-co-glycolic acid)(PLGA) nanoparticles for controlled NO release. PLGA is a biocompatible and biodegradable polymer approved by the FDA for the use of drug carriers. We prepared PLGA nanoparticles by different copolymer ratios and investigated physicochemical properties of PLGA nanoparticles. We compared the release profiles depending on the degradation rate of nanoparticles and optimized NO releasing PLGA nanoparticles for proper treatment. |
