| 초록 |
Nitric Oxide (NO) is an endogenous radical gas molecule involved in physiological processes. However, because of the very short half-life, NO can be easily removed in a physiological environment. Therefore, NO should be delivered topically at the target site as a precise concentration. Hydrogel is a promising carrier for topical delivery of drug offering excellent biocompatibility. But chemically crosslinked hydrogel has a complicated preparation process unsuitable to adapt in NO delivery. Otherwise, laponite (LP) is a certain clay known for the ability of easily-forming hydrogel in water. In this study, to take advantage of the topically retaining property and easy-forming process of LP hydrogel, we introduced LP hydrogel for topical delivery of NO. Furthermore, we investigated tube formation with the human umbilical vein endothelial cells to confirm in vitro angiogenic property of nitric oxide releasing LP hydrogel as a regenerative microenvironment. |
