| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Long term Toxicity study of QDs loaded Heparin-DOCA conjugates |
| 초록 |
Nanometer-scale semi-conductor quantum dots (QDs) have attracted widespread interest in medical diagnosis and treatment, though many can have intrinsic term toxicities, especially those composed of CdSe. Here we compare the toxicity studies which were carried out to observe the toxic effects of Cd2+. QDs-loaded Heparin-DOCA conjugates have been shown lees toxicity and comparatively safer for live cell and animal due to loading with Heparin-DOCA conjugates. Content of QDs which were present in different organs part analyzed by varioskan flash. Finally the collected blood sample were analyzed by ICP-MS to count the remaining Cd2+ into the sensitive organs and histological section of liver and small intestinal parts were collected 45 days post oral administration of QDs loaded Heparin-DOCA conjugates. Our designed oral delivery imaging agents has been proved as safe and effective for GIT imaging. |
| 저자 |
이용규, Zehedina Khatun, 누런나비엠디
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| 소속 |
충주대 |
| 키워드 |
Toxicity; Quantum dots; H&E staining.
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| E-Mail |
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