| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Oral therapeutic agents delivery using transport system |
| 초록 |
The precedence in oral delivery of biomolecules in targeting dreadful diseases like cancer is yet to be achieved since the GI barriers hamper their pharmacokinetics, stability and bioavailability. We devised GLP-1 pDNA and siRNA based oral gene delivery systems to treat T2DM and hepatic cancer respectively. The results were very promising where a singular dose of our engineered GLP-1 non-viral vectors could revamp the lost incretin effects in animal models and aid in regulating the insulin and blood glucose levels under homeostatic glycemic ranges for 21 days without inducing any systemic toxicity. We further aim to investigate the mechanisms involved in improving the therapeutic efficacies of our formulations over conventional oral gene delivery systems. The objective is to move towards developing a “gene pill” based platform technology and create a new hope in Translational medicine. |
| 저자 |
이용규 |
| 소속 |
한국교통대 |
| 키워드 |
oral delivery; GLP-1; gene delivery
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| E-Mail |
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