| 초록 |
Poly (ethylene glycol) (PEG) is a polymer of biomedically widely adapted to lengthen bloodstream-circulation time and shorten frequency of non targeted interaction for pharmaceuticals. The size, geometry, and attachment site of the PEG moiety play such a critical role in determining the pharmacokinetics of the functionalized pharmaceutical that therapeutically optimized agents must be designed on a case-by-case basis. Advent of nanotechnology has attritubed to biomedical advancemnet. Particularly, enhanced efficacy in cancer treatment using spherical nanoparticles has been reported. The nanoparticles have also utilized PEG passivationto reduce unwanted protein adhesion under untargeted local or systemic delivery. Due to the different behavior of PEG immobilized on the surface of nanoparticles depending on the size and immobilized density, there have been few trials to determine conformation of PEG on the nanoparticles. Therefore we report the first our analysis of conformational changes of PEG on gold nanoparticles depending on their molecular size and immobilized density. |
