| 초록 |
There is a lot of interest in safe and improved imaging for cancer therapy. Bioimaging modalities based on X-ray radiation, magnetic resonance and computed tomography suffer from limitations with respect to safety, cost or lack of adequate contrast. Furthermore, only one imaging modality for the treatment of cancer has limitation for accurate detection of tumor sites. Ultrasound and photoacoustic imaging are highly complementary modalities since both use ultrasonic detection for operation. Here, we developed thermo-sensitive Pluronic nanoparticle based ultrasound and photoacoustic imaging agents that can stably load perfluorocarbon and dye molecules. We conducted TEM, DLS and Bio-imaging intensity analysis. Finally, we could successfully carried out the high intensity ultrasound induced ablation of tumor tissues ex vivo. Taken together, we could confirm the feasibility of PEG cross-linked Pluronic nanoparticles for cancer ablation therapy. |
