| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Gold Nanoshell and Dendrimer Porphyrin Covered Multifunctional Nanoparticles for Combined Phototherapy of Cancer |
| 초록 |
Photodynamic therapy (PDT) is excellent method for the treatment of cancer. It involves the systemic administration of photosensitizers (PS) such as porphyrin and phthalocyanine, so PS transfers photon energy to generate cytotoxic reactive oxygen species (ROS) to kill cancer. In the case of photothermal therapy (PTT), it involves the conversion of absorbed photon energy into the heat by using gold nanomaterials. In this work, 3rd generation dendrimer porphyrin was deposited onto gold nanoshell coated silica nanoparticles via Layer-by-Layer method. The successful fabrication of this system was monitored by UV–Vis spectroscopy, high resolution TEM, and electrophoretic light scattering spectrophotometer. Also, photodynamic and photothemal effect of nanoparticles under light exposure was confirmed by conducting ROS generation and temperature increase test. Furthermore, synergetic combined phototherapy including PDT and PTT was achieved through cell viability using the MTT assay. |
| 저자 |
고원건, 장우동, 방혜정, 조강희, 김민수, 민지홍, 정의석
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| 소속 |
연세대 |
| 키워드 |
gold nanoshell; dendrimer porphyrin; cancer; phototherapy
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| E-Mail |
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