| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Dual Targeting pH/NIR-absorbing Fluorescent Polydopamine Crosslinked Hyaluronic Acid for Chemo-phototherapy |
| 초록 |
This research investigated the efficacy of therapeutic platform based on a stimulus agent and dual targeting nanocarrier for a photothermal-guided bioimaging and chemotherapeutic treatment. The inclusion complex formed from conjugation of hyaluronic acid (HA), triphenylphosphonium (TPP) and β-cyclodextrin (CD)–diol linked boronic acid (BA) for loading of paclitaxel (PTX) created a shell-like structure based on a carbonized fluorescent polydopamine nanoparticles (FNPs-pDA) core, which can combine bioimaging with photothermal effect. The core@shells nanocarriers of [FNPs-pDA@HA-TPP-CD-PTX] that can both extracellularly targeting via HA- and intracellularly targeting via TPP, creating a dual targeting system. The nanoparticle was development from the cross-linked of FNPs-pDA with the boronic acid groups of HA-TPP-CD-PTX that will enhance the boronate esters formation which will be utilized as pH-mediated photothermal activity. |
| 저자 |
이운한, 박성영
|
| 소속 |
한국교통대 |
| 키워드 |
Hyaluronic Acid; Triphenylphosphonium; Paclitaxel; Chemo-photothermal therapy
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| E-Mail |
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