| 학회 |
한국화학공학회 |
| 학술대회 |
2011년 가을 (10/26 ~ 10/28, 송도컨벤시아) |
| 권호 |
17권 2호, p.1184 |
| 발표분야 |
고분자 |
| 제목 |
Synthesis and characterization of polyaspartamide derivatives for theranostic application |
| 초록 |
A series of biodegrabable graft copolymer polyaspartamide derivatives were synthesized by grafting of O-(2-aminoethyl)-O'-methylpoly(ethylene glycol) 5000(MPEG) on polysuccinimide(PSI), and conjugeted doxorubicin with linkers of acid-sensitive hydrazone bond. This hydrazone bonds can be cleaved most effectively in an intracellular acidic environment. and conjugeted cholic acid as hydrophobic moieties. The chemical structure of the polymer and the degree of substitution of the prepared polymer was confirmed using FT-IR and 1H NMR spectroscopy. Their pH-sensitive properties were characterized by light transmittance measurements, and the mean particle size and their distribution were investigated by dynamic light scattering measurement through varying pH values. And this polymeric micelle can be a potential carrier for the drug delivery system. |
| 저자 |
임철원, 김덕준
|
| 소속 |
성균관대 |
| 키워드 |
polyaspartamide; hydrazone bond; drug delivery
|
| E-Mail |
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| 원문파일 |
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