| 초록 |
Stem cells are being extensively studied as a new generation of medical therapy because of their ability to sustainably produce therapeutic proteins and recreate new tissues. However, the therapeutic stem cells lack a capacity to detect and adhere to the target tissue. Therefore, this study presents synthesis of a bioactive hyperbranched polyglycerol (HPG) which can associate with stem cells and further guide them to target sites, such as inflamed endothelium. We envisage that the strategy using a HPG carrier to bind cells and display targeting groups for delivery, would be highly useful for guiding a wide array of therapeutic cells to target tissues following intravascular injection. J. Am. Chem. Soc., 2013 (24), 8770-8773 |
