| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
The effects of microneedles for transdermal permeation of FITC-BSA. |
| 초록 |
To penetrate large molecules such as vaccine and protein drug(FITC-BSA) through skin treated with microneedle. FITC was dissolved in PBS and BSA was dissolved in DMSO. Two solutions were mixed at 4℃ and were stirred for 24h in the darkroom. Skin kept in 0.9% NaCl solution at 30min and treated with microneedle. The volume of 4mL PBS was added in Fransz-diffusion cell, and PBS 2mL was collected with time. It was analyzed fluorescent spectroscopy. The group of using 4R showed the highter rate than non treated and 2R types through the skin. We confirmed that permeation rate of BSA was increased with the treatment by microneedle and was increased by the increasing frequency of treatment. This research was supported by MHWFA(0405-BO01-0204-0006) and WCU(R31-20029). |
| 저자 |
박현진, 김윤태, 홍희경, 안식일, 김혜린, 이동원, 이종문, 강길선
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| 소속 |
전북대 |
| 키워드 |
microneedles; transdermal;
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| E-Mail |
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