| 초록 |
The badly postoperative adhesions cause pelvic pain, infertility, and intestinal obstruction. Hydrogel barriers have many advantages such as biodegradability, non-toxicity, non-preform, flexibility, high permeability of oxygen, nutrients. We developed the in situ injectable crosslinked-hydrogel fabricated by modified carboxymethyl cellulose(CMC) with tyramine and subsequent enzyme reaction using horseradish peroxidase(HRP) and H2O2, and additionally add pullulan into hydrogel solution for improving adhesive strength and accelerating biodegradation. The modified CMC with tyramine was confirmed by ATR-FTIR. The biodegradation behavior was observed by weigh loss and SEM images of the gel. In vivo animal test, post-operative tissue adhesion was dramatically decreased by applying in situ injectable hydrogel. From these results, it is concluded that the injectable hydrogel made of modified CMC and pullulan has great potential for use as an anti-adhesion barrier. |
