| 초록 |
The biological machine was designed to self-transform using a multi-layered hydrogel. The biological machine’ legs consisting of two layers with different swelling ratios were fabricated to have 5.3 mm of radius of curvature by self-folding assembly at 37°C. The hydrogels patterned with three different geometries by the micro-contract printing could influence the differentiation process and alignment of C2C12 skeletal myoblasts. The cells on the linear patterns resulted in the 3.6-fold increase of the contractile force with 1.12±0.30 μN, as compared to the cells on the circle patterns with 0.31±0.32 μN of contractile force. Overall, this new strategy to prepare the biological machine with the multi-layered hydrogel would be actively used in drug delivery, tissue engineering, environmental engineering, and biomimetic engineering, etc. |
