| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Cellulose-graft-poly(l-lactide) micelle for drug delivery vehicle: Effect of degree of substitution on the micelle stability and drug release behavior |
| 초록 |
A biodegradable water-soluble cellulose-graft-poly(l-lactide)(cellulose-g-PLLA) with various degree of substitution was synthesized in 1-butyl-3-methylimidazolium chloride using stannous octanoate as an initiator. The characterization of the cellulose-g-PLLA was measured by 1H-NMR, GPC and contact angle meter. The cellulose-g-PLLA could self-assemble into micelles in water with the hydrophobic PLLA segments at the cores of micelles and the hydrophilic cellulose segments at the outer shells. The hydrodynamic diameters of cellulose-g-PLLA micelle had a range from 100 to 200nm. Prednisone acetate, a water insoluble anti-inflammation drug, was chosen as a model drug to investigate the utilization of micelles as a delivery carrier. The cellulose-g-PLLA micelle with low degree of graft substitution had higher micelle stability and sustained drug-release behavior from the micelles. |
| 저자 |
이가현1, 이성준1, 정상원1, 김은주1, 김현철1, 서송이1, 최진현2, 이세근1
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| 소속 |
1대구경북과학기술원, 2경북대 |
| 키워드 |
Cellulose; drug delivery; micelle stability
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| E-Mail |
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