| 초록 |
Heparin, a widely used anticoagulant, is known to have multiple anticancer mechanisms, including inhibition of tumor angiogenesis, interference with tumor cell adhesion, and suppression of tumor cell invasion. In this study, a polymeric particulate drug delivery system was designed by using heparins as the hydrophilic backbone for its anti-tumor activities. The drug-loaded hydrophobic part was conjugated on the side chain of heparins. In addition, the heparin-based drug carriers were designed by importing ligands on the hydrophilic backbone to achieve active tumor targeting for effective cancer treatment. |
