| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Drug Release Behaviors of Heparin-Based Nanoparticles for Tumor-Targeted Drug Delivery |
| 초록 |
A novel heparin-based copolymer heparin-poly(β-benzyl-L-aspartate) (HP) was synthesized as anticancer drug carrier. In order to develop an active tumor-targeted drug delivery system, folate ligands were introduced onto heparin-based nanoparticle. The heparin-based copolymers were found to have low anticoagulant activity, which was suggested to be safe drug carriers without the risk of inducing hemorrhage. The encapsulation of Paclitaxel (PTX) in polymeric micelles composed of heparin-based copolymers was investigated in this study. The drug loading content, encapsulation efficiency and in vitro drug release profile were characterized. The size of PTX-loaded micelles was in the range of 150-200 nm at high drug loading efficiency, which indicated the potential capacity for targeting solid tumor tissues passively by the Enhanced Permeability and Retention (EPR) effect. These findings showed that the HP and FHP copolymers could be useful as hydrophobic anticancer drug carriers. |
| 저자 |
이립1, 이용규2, 허강무3, 김소연3
|
| 소속 |
1chungnam national Univ., 2충주대, 3충남대 |
| 키워드 |
heparin; drug delivery; polymeric micelle; anticancer drug
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| E-Mail |
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