| 초록 |
Aptamers are an emerging class of targeting ligands that also serve as biological drugs that can be used to treat various diseases. In the first part of my talk a targeted drug delivery system of Dox to the prostate tumour based on PSMA-specific aptamer conjugated dendrimer will be presented. The Dox-loaded PSMA aptamer conjugated dendrimer exhibited excellent antitumor efficacy on in vivo prostate tumor models compared to control groups. In the second part, I will present a multifunctional nanoparticle for targeted molecular CT imaging and therapy of prostate cancer. By functionalizing the surface of gold nanoparticles (GNPs) with a PSMA-specific A9 RNA aptamer, we established a targeted molecular CT imaging system capable of specific imaging of prostate cancer cells that express the PSMA protein. Furthermore, the aptamer-conjugated GNPs after loading of doxorubicin were significantly more potent against targeted LNCaP cells than against non-targeted PC3 cells. |
