| 학회 |
한국화학공학회 |
| 학술대회 |
2011년 봄 (04/27 ~ 04/29, 창원컨벤션센터) |
| 권호 |
17권 1호, p.403 |
| 발표분야 |
생물화공 |
| 제목 |
Development of succinic acid-tolerant Mannheimia succiniciproducens based on transcriptome analysis |
| 초록 |
A genetically engineered M. succiniciproducens strain for succinic production was adaptively evolved for improved succinic acid tolerance. Immediate and delayed responses of the parent strain and the mutant strain to succinic acid shock were analyzed in transcriptome level by DNA microarray. Gene expression levels of the mutant strain were compared with a parent strain and the gene expression patterns were classified refer to function of genes. Overexpression of gene encoding the carboxylic acid transporter selected based on the transcriptome analysis increased growth rate of the parent strain in the medium with succinic acid of high concentration. [This work was supported by the Korean Systems Biology Research Project (20100002164) of the Ministry of Education, Science and Technology (MEST) through the National Research Foundation of Korea. Further support by the World Class University Program (R32-2008-000-10142-0) through the National Research Foundation of Korea funded by the MEST is appreciated.] |
| 저자 |
김유빈, 이종호, 백종환, 이상엽
|
| 소속 |
카이스트 |
| 키워드 |
Mannheimia succiniciproducens; succinic acid; DNA microarray
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| E-Mail |
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| 원문파일 |
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