| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
[정밀화학] 정밀화학 기술 - COVID-19 시대 |
| 제목 |
Mesoporous Silica-Based Immunotherapy |
| 초록 |
Immunotherapy has been recognized for decades as a promising therapeutic method for cancer treatment. To enhance host immune responses against cancer, antigen‐presenting cells or T cells needs to be activated using appropriate immunomodulatory agents. In this talk, our recent findings on application of injectable mesoporous silica particles as a platform for cancer immunotherapy will be introduced. The microsized mesoporous silica particles could be spontaneously stacked after injection into body and generate 3-dimensional structure with interparticular pores where a high number of DCs are recruted. The subsequent delivery of nanosized vaccines carrying protein antigen or antigen-coding DNAs to the recruited DCs provoke antigen-specific T cell responses and suppress tumor growth. These findings suggest that mesoporous silica could be used as an efficient vaccine platform for cancer immunotherapy. |
| 저자 |
김재윤 |
| 소속 |
성균관대 |
| 키워드 |
immunotherapy; vaccine; mesoporous silica; dendritic cells; T cells
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| E-Mail |
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