| 초록 |
Sub-micrometer scale polymeric gels offer significant advantages as drug delivery vehicles compare to micrometer scale polymeric gels. Because of the small size of sub-micrometer scale polymeric gels, the efficiency of drug or gene delivery to the target tissue, and the stability of therapeutic agents against chemical/enzymatic degradation can be improved. Microfluidic devices made of polydimethylsiloxane (PDMS) can provide a versatile approach to prepare monodisperse droplets at high frequencies. However, the conventional 2-D microfluidic flow-focusing devices are not widely used for the production of submicrometer-scale droplets. In this work, we fabricated new 3-D flow focusing devices to generate polyethylene glycol diacrylate droplets at the submicrometer-scale. We expect that the continuous production of monodisperse nanogels can offer numerous advantages for the development of drug delivery vehicles. |
