| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.650 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation of PLGA-collagen nanofiber scaffolds by electrospinning and their interaction with fibroblasts |
| 초록 | Introdution Poly(lactide-co-glycolide) (PLGA), the random copolymer of poly(lactide) (PLA) and poly(glycolide) (PGA), has been widely used for medical applications such as surgical suture, temporary scaffolds for tissue engineering, and drug carriers because of the complementary nature of PLA and PGA. Both PLA and PGA are biodegradable and biocompatible. Collagen is a biodegradable, biocompatible, and non-immunogenic structural protein, which makes it a suitable compound for a variety of biomedical application. Recently, much attention has been paid to electrospinning process as a unique technique because it can produce nanofiber scaffolds with diameter in the range from several micrometer down to tens nanometers. With respect to surface microstructure, nanofibrous scaffolds are the most promising materials used in various tissue-engineering applications because of their high specific surface area and highly porous three-dimensional structure. In this study, the blend solution of PLGA and collagen typeⅠwere used to fabricate electrospun nanofiber scaffold. Characteristics of nanofiber scaffolds were investigated using ATR-FTIR spectroscopy and electron spectroscopy for chemical analysis. Behaviors of fibroblasts on nanofiber scaffolds were also investigated. Results and Discussion The SEM micrograph of nanofibrous electrospun from the PLGA/collagen solution was shown in Figure 1. PLGA-Col nanofibers with diameters ranging from 0.2 to 0.7㎛ were formed. Figure 2 shows the fibroblasts grown on the fiber mat for 4 h. The SEM micrograph showed that the fibroblasts adhered, spread, and proliferated on the surface of PLGA-collagen nonwoven mat. This results suggest that PLGA-collagen can provide a good micro-environment for the cells. |
| 저자 | 맹 만1, 김정철2, 권오형3, 강인규1 |
| 소속 | 1경북대, 2경북대하교 의과대, 3금오공대 고분공학과 |
| 키워드 | PLGA; collagen; electrospinning; nanofiber; fibroblast |
