| 초록 |
Various biomacromolecules (BMs) such as proteins, DNA, and carbohydrates, are extremely difficult to be dissolved in a single organic solvent phase for sustained release or targeted delivery formulation. In this study, three different BMs could be solubilized in selected organic solvents by forming PEG-assisted nano-complexes while maintaining their structural integrity. DLS and AFM analysis revealed that proteins, DNA, and carbohydrate polymers could be nano-complexed with PEG in various organic solvents. The diameter of nano-complexes decreased roughly from ~ 600 nm to ~ 100 nm with increasing the weight ratio of PEG/BM. The present solubilization technique could be potentially applied for sustained release formulations of various therapeutic biological drugs. |
