| 초록 |
In order to develop novel antibiotic peptides useful as therapeutic agents, potent antibiotic activities against bacteria, fungi and cancer cells without a cytotoxic effect are essential. To this end, several analogue peptides with amino acid substitutions were designed to increase or decrease only the net hydrophobicity. To investigate the antibiotic activity and synergistic effect against MDR and biofilm-forming strains, analogues were performed about the antibacterial activity in minimal inhibition concentration (MIC) and minimal bactericidal concentration (MBC) without having hemolytic activity. In addition, the peptide (A3) showed a strong antimicrobial activity against ciprofloxacin-resistant P. aeruginosa (CRPA) in vivo and the cochlear tolerance of A3 was studied in vivo by topical application to the middle ear in guinea pig model. |
