| 초록 |
Polysaccharide derivatives have been extensively studied as chromatographic chiral selectors in chiral stationary phases(CSPs) for the separation of enantiomers. As a result, many chiral stationary phases(CSPs) have been prepared, and some of them have been commercialized and used not only for determining optical purity of enantiomers but also for obtaining optically pure enantiomers. Hence, in our study, chitosan,which has good enantioselectivity and is convenient for chemical modifications at the free amino groups, was used as a starting material for the preparation of CSPs. L-phenylalanines were nicotinoylated with an active ester synthesized from nicotinic acid and N-hydroxysuccinimide. The synthesized N-nicotinoylated phenylalanines were coupled with chitosan. We can expect to be some possibilities of chiral recognition by spacer arms. In the next step, N-(N-nicotinoyl-L-phenylalanyl)-chitosan bis-(3,5-dimethylphenylcarbamates) can be synthesized by reacting the remaining hydroxyl groups of the chitosan derivative with an excess amount of 3,5-dimethylphenylisocyanate. |
