| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | HOW FAST SHOULD DRUG NANOCRYSTAL DISPERSIONS BE FROZEN? – Preventing Polymer Entanglement |
| 초록 | Recent advances in nanoparticle technologies have significantly enhanced the oral and parenteral delivery of poorly water-soluble active pharmaceutical ingredients (APIs). However, reports have been limited on the various drying procedures to convert a liquid nanocrystal dispersions into solid dosage forms. The solid dosage form should consist of nanocrystals that can readily reconstitute into their original size upon dissolution in water. Herein, the freeze drying process of nanocrystal dispersions was examined at varying freezing rates (speed of freezing interface). As freezing rate decreases, more particle-particle aggregation developed. A critical freezing rate, below which the dried nanocrystals cannot be re-dispersed, was identified based on the plot of the particle size of reconstituted nanocrystals versus freezing rate. Freeze drying at a freezing rate near the critical value produces dry powders of bimodal particle size distribution after re-dispersion. In addition, API concentration was found to significantly affect the critical freezing rate and therefore the re-dispersibility of dry powders. The concept of critical freezing rate is critical for the development of solid dosage forms of liquid nanocrystal dispersions. [1] J. Lee, Drug nano- and microparticles processed into solid dosage forms: physical properties, J. Pharm. Sci., 92(10) (2003) 2057-2068. [2] M.J. Grau, O. Kayser, R.H. Müller, Nanosuspensions of poorly soluble drugs – reproducibility of small scale production, Int. J. Pharm., 196 (2000) 155-157. [3] R. Liu (Ed.) Particle size reduction, in water-insoluble drug formation, Buffalo Grove: Interpharm Press, 2000, pp. 455-492. |
| 저자 | 김미종1, 이종휘1, 김민영1, 최지연2, 박철호1, 유지연1 |
| 소속 | 1중앙대, 2세종대 |
| 키워드 | Drug nanoparticle; Pharmaceutical formulation; Freeze drying; Re-dispersable |
