| 초록 |
Recently, much attention has been paid to electrospinning process as a unique technique because it can produce polymer nanofibers with diameter in the range from several micrometer down to tens of nanometers, depending on the polymer and processing conditions. In electrospinning, a high voltage is applied to create electrically charged jets of a polymer solution. These jets dry to form nanofibers, which are collected on a target as a nonwoven fabric. These nanofibers are of considerable interest for various kinds of applications, because they have several useful properties such as high specific surfac area and high porosity. Examples are fiber membranes for filter applications, biomedical applications such as wound dressings and scaffolds for tissue engineering, sensing applications. Nonwovens composed of electrospun nanofibers have highly porous and three-dimensional structure. They are architectually similar to collagen structure of extracellular matrix, in which collagen multi-fibrils of nanometer scale are composed of three dimensional nework structure together with proteoglycans. Also, high porosity of electrospun nonwovens can provide a higher cell density. The ultimate aim of this study is to develop wound dressings composed of the electrospun SF nanofibers. In this study, the morphological characterization of electrospun SF nanofibers was conducted, and the cell activities of hunam oral and epithelial keratinocytes on SF nanofiber scaffolds were investigated.
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