| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.302 |
| 발표분야 | 기능성 고분자 |
| 제목 | Preparation of pH- and Temperature-sensitive Hydrogel Microspheres and Drug Release Properties |
| 초록 | Microspheres of poly(N-isopropylacrylamide-co-N-butoxymethylacrylamide) (Poly(NIPAAm-co-nBMA)) and poly(N-isopropylacrylamide-co-acrylic acid)(Poly(NIPAAm-co-AAc)), cross-linked with N-N'-methylene bisacrylamide (NMBA), were synthesized using precipitation polymerization. Through the differencial scanning calorimeter, dynamic light scattering, scanning electron micrescope analysis, lower critical solution temperature and the variation of diameter of the microspheres were measured. The effect of temperature and pH on the microspheres was investigated. Both poly(NIPAAm-co-nBMA) and poly(NIPAAm-co-AAc) MIS are temperature sensitive. Variations in pH were found to effect the size of poly(NIPAAm-co-AAc) which contained the ionizable groups such as carboxylic acid. The increased electrostatic repulsion of charged groups with increasing pH was the main reason. The controlled release studies were conducted for their MIS using Hymexazole, water-soluble herbicide. Release behavior was studied under various conditions, over a range of temperature and pH. Figure 1 Figure 2 Figure.1 DSC thermograms of microspheres. Figure 2. Diameter of microspheres, at 23℃(left) and at 40℃(right). Reference 1.. G.Huanga, J. Gaoa, and Z. Hua,Journal of Controlled Release 94 (2004) 303-311 |
| 저자 | 양승훈, 김형일 |
| 소속 | 충남대 |
| 키워드 | microsphere; stimuli-responsive; precipitation polymerization |
