| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
All-Trans Retinoic Acid Release from Polyion Complex Micelles of Methoxy Poly (ethylene glycol)-grafted-Chitosan |
| 초록 |
We synthesized methoxy poly(ethylene glycol)-grafted chitosan (ChitoPEG) copolymer to prepare RA-encapsulated polymeric micelle. RA-encapsulated polymeric micelle of ChitoPEG copolymer is 100-500nm in particle size and has spherical shape when observed by TEM. In 1H NMR study, the specific peaks of RA and chitosan as a drug carrying innercore disappeared at D2O and only the specific peak of MPEG was observed, while specific peaks of MPEG, RA, andchitosan appeared at DMSO. This indicates that RA/ChitoPEG ion complexes are composed of polymeric micelle with a core-shell structure, and that free drug does not exist on the polymeric micelle formulations. Another evidence of drug-incorporation into polymeric micelle was witnessed in a DSC analysis. The melting peaks of RA and chitosan were 182 oC and 220 oC, respectively. |
| 저자 |
김동곤1, 정영일1, 박준규1, 장학수1, 장민자1, 권중근2, 서동혁1, 장미경1, 나재운1
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| 소속 |
1순천대, 2조선이공대 |
| 키워드 |
All-trans retinoic acid; chitosan; Polyion complex.
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| E-Mail |
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