| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Enhancement of the drug permeability by the nail swelling |
| 초록 |
There are two methods which are administration of oral formulation and application of topical agent for the treating onychomycosis. In this study, drug effectively was penetrated by chemical modification of nail for the topical treatment. For the modification of nail, penetration enhancer, acids, bases, mordants, reducing agents, oxidizing agents etc, had been used. And we calculated the nail swelling(%) by weighing the nails before and after being treated with penetration enhancer and expected the absorption of drug. Moreover we examined the drug absorptivity and changes of nail morphology, according to conducting the fluorescence staining and H&E staining. Finally, it is not easy that drug is penetrated through the nail. Because the nail is made of dead keratin multi layer which is tightly packed. Treated with some penetration enhancers used in this study, we confirmed the effective drug penetration by modifying the nail morphology. |
| 저자 |
안식일, 엄신, 김용기, 최진희, 이동원, 유일수, 이종문, 강길선
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| 소속 |
전북대 |
| 키워드 |
Nail swelling; enhancer; penetration; nail
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| E-Mail |
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