| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Polysaccharide conjugated cyclodextrin complexes as a sustained drug delivery system |
| 초록 |
In recent years, much attention has been focused on the investigation of self-assembled supramolecular system based on cyclodextrin (CyD), naturally occurring water-soluble oligosaccharides. The ability of CyD to form unique inclusion complexation, with various small molecules like drugs and polymers, have been widely exploited in the pharmaceutical for the development of stable and sustained release formulations. In the present work, polysaccharide conjugated CyD was synthesized and characterized using 1H-NMR. Their complexation behavior with PEGylated protein was studied using PEG-human growth hormone (hGH) as a model protein. The complex was further cross-linked using Micheal type addition reaction. The drug release profile from both the cross-linked and uncross linked system was evaluated. |
| 저자 |
김유정1, Maharajan Sivasubramanian1, 채수영2, 이강춘2, 박재형1
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| 소속 |
1경희대, 2성균관대 |
| 키워드 |
Polysaccharide; Cyclodextrin; PEGylation; Michael type additon reaction
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| E-Mail |
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