| 초록 |
The gold-nickel multi-segmented nanorod was fabricated by electrodeposition into an Al2O3 template with a pore diameter 100nm. A gold segment was chemically modified with Pluronic F-127 to encapsulate excessive amounts of doxorubicin around the nanorod and a nickel segment was decorated with folate to confer an active targeting moiety toward cancer cells. Thiol-modified Pluronic F-127 was conjugated to gold segment and a carboxyl group of folate was attached to nickel segment. In Pluronic F-127 modified rods, doxorubicin was reversibly encapsulated to the rods according to temperature change from 4°C to 37°C. Doxorubicin was maximally encapsulated around the modified nanorods at 37°C and a full extent of doxorubicin release was observed at 4°C. Further studies are required to determine amounts of drug loading according to gold segment length, targeting effects of folate. With this results, nanorods should be employed nanorods as multifunctional anti-cancer drug carriers. |
