| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synthesis and Characterization of Anisotropic Polypeptide Nanoparticles with Opposite Charges for Advanced Drug Delivery |
| 초록 |
Biopolymer-based anisotropic nanostructures with distinct multi-compartments could be of great interest for development of advanced drug delivery systems because they are capable of controlling drug release kinetics at each compartment. In this study, anisotropic elastin-based polypeptide (EBP) nanoparticles with discrete polarity were synthesized and characterized. Two oppositely charged EBPs were genetically engineered, expressed in E. coli and purified via inverse transition cycling, followed by introduction of hydrophobic moieties to the functional groups of EBP side chain for stabilization. Furthermore, dipolar EBP nanoparticles with oppositely charged compartments were prepared with two different hydrophobically-modified EBPs via electrohydrodynamic co-jetting and their colloidal assembly was evaluated. Potentially, the anisotropic polypeptide nanoparticles with opposite charges could be useful for drug delivery, molecular imaging and guided self-assembly. |
| 저자 |
이재상1, 강민정2, 임동우3
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| 소속 |
1Department of Bionanotechnology, 2Hanyang Univ., 3ERICA Campus |
| 키워드 |
Thermal responsiveness; elastin-based polypeptides; anisotropic nanoparticle; electrohydrodynamic co-jetting; drug delivery systems
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| E-Mail |
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