| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Molecular Design, Expression and Characterization of Elastin-Resilin based Block Copolymers for Injectable Hydrogels |
| 초록 |
Protein-based block copolymers for injectable hydrogels have been widely studied for functional tissue engineering applications. In this study, elastin-resilin based block copolymers with different block lengths were genetically engineered, expressed, and purified by inverse transition cycling. This work was motivated to combine unique thermo-responsiveness of elastin-based polypeptides (EBPs) with high resilient property of resilin-like polypeptides (RLPs) for formation of self-assembled hydrogel network with high elasticity and resilience. The EBP blocks at both ends formed hydrophobic aggregate domains above their transition temperatures while the RLP blocks with high resilience being hydrated, resulting in formation of physically cross-linked hydrogels via temperature-triggered self-assembly. In conclusion, these elastin-resilin based block copolymers would be promising as injectable hydrogels for tissue engineering and regenerative medicine. |
| 저자 |
앙나 바쉬르1, 이재상2, 강민정3, 임동우1
|
| 소속 |
1Department of Bionanotechnology, 2Hanyang Univ., 3ERICA Campus |
| 키워드 |
Resilin; Elastin; Block copolymers; Physical cross-linking; Tissue engineering
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| E-Mail |
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