| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Superparamagnetic Iron Oxide Nanoparticles (SPIONs) Coated with Galactose-carrying Polymer for Hapatocyte Targeting |
| 초록 |
Our goal is to develop the functionalized SPIONs demonstrating the capacities to be delivered in liver specifically and to be dispersed in physiological environment stably. For this purpose, SPIONs were coated with poly(vinylbenzyl-O-β-D-galactopyranosyl-D-gluconamide) (PVLA) having galactose moieties to be recognized by ASGP-R on hepatocytes. For use as a control, we also prepared SPIONs coordinated with 2-pyrrolidone. The sizes, size distribution, structure, and coating of the nanoparticles were characterized by TEM and ELS, XRD, and FT-IR, respectively. Intracellular trafficking of the PVLA-coated SPIONs was visualized by confocal laser scanning microscopy and their hepatocyte-specific delivery was also investigated through MRI of rat liver. MRI experimental results indicated that the PVLA-coated SPIONs possess the more specific accumulation property into liver in comparison with control, which suggests their potential utility as liver-targeting MRI contrast agent. |
| 저자 |
유미경1, 김은미2, 김인용3, 정환정4, 이창문1, 정용연2, Toshihiro Akaike3, 조종수3
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| 소속 |
1서울대, 2농생명공학부, 3전북대, 4핵의학과 |
| 키워드 |
Superparamagnetic iron oxide nanoparticles; poly(vinylbenzyl-O-β-D-galactopyranosyl-D-gluconamide); liver targeting; magnetic resonance imaging; contrast agent
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| E-Mail |
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