| 학회 |
한국공업화학회 |
| 학술대회 |
2005년 가을 (10/28 ~ 10/29, 건국대학교) |
| 권호 |
9권 2호 |
| 발표분야 |
고분자 |
| 제목 |
Effect of Surface Modification of Poly (methyl methacrylate) Intraocular Lenses with Hydrophilic Monomers on Plasma Protein Adsorption |
| 초록 |
Surface modified PMMA IOLs with acrylic acid and acrylamide were prepared via plasma-induce graft polymerization, and plasma proteins bound to the prepared surfaces were analyzed by one- and two- dimensional PAGE together with western blot analyses. Changes in complement components due to the contact of prepared IOLs were also studied by using ELISA. PMMA-g-AAc and PMMA-g-AAm IOLs exhibited that plasma protein bound were more than that of PMMA. And western blot and 2D PAGE results showed that albumin was the most abundant protein in all the samples. The proportion of adsorbed fibrinogen, Ig G, and transferrin to PMMA-g-AAc IOLs exhibited the lowest. Surface modified PMMAs activated complement components to a lesser extent than did PMMA. These results indicated that these surface modifications may improve the plasma protein adsorption and complement activation. |
| 저자 |
유규은, 김만수, 전흥재
|
| 소속 |
가톨릭대 |
| 키워드 |
PMMA-g-AAc IOLs; PMMA-g-AAm IOLs; plasma protein adsorption; complement activation
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| E-Mail |
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