| 초록 |
The capabilities to inducestable gene expression and gene targeting within stem cells will be powerful research tools for a variety of applications, including mechanistic analysis of cell differentiation and proliferation, methods for tracking transplanted stem cellsin vivo, and ways to correct deleterious genetic mutations. In this presentation, a powerful tool (i.e. directed evolution) to create de novo bio-inspired nanoparticles (i.e., AAV vectors) that can significantly enhance the capabilities of gene targeting within stem cells will be introduced, and a variety of potential applications using gene-targeted stem cells will be discussed. |
