| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Optimization of the Preparation and Characterization of Tannylated-Albumin Nanoagent |
| 초록 |
We optimized the preparation of tannylated-human serum albumin (TA-HSA) nanoagents including indocyanine green (ICG) and lobeglitazone-loaded complexes by simple mixing and characterized them. We set the optimal pH at 5 and the optimal weight ratio of [TA]/[HSA] at 1.5 when considering the redispersion of the prepared suspensions in PBS (pH 7.4) and incubation at 37°C for the preparation of ICG and/or Lobe-loaded TA-HSA complexes. The immobilization of methoxy polyethylene glycol (mPEG) molecules on TA-HSA-ICG complexes significantly reduces the mean and Z-average sizes of these complexes from the microscale to the nanoscale. Moreover, the use of ICG increases the drug loading efficiency when preparing mPEG-TA-HSA-ICG/Lobe. |
| 저자 |
송영준, 정성윤, 김진혁, 박경순
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| 소속 |
중앙대 |
| 키워드 |
tannic acid; albumin; protein-based carrier; nanoagent.
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| E-Mail |
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