| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Light-induced degradation of ROS-sensitive mPEG-b-PPADT micelles for anticancer drug delivery |
| 초록 |
ROS-sensitive poly-(1,4-phenyleneacetone dimethylene thioketal) (PPADT) nanoparticles were reported for the oral delivery of therapeutic siRNA to inflammation sites in the intestine. Here, ROS-sensitive polymeric micelles (RPMs) were fabricated using an amphiphilic block copolymer of PPADT and poly(ethylene glycol) (PEG) with co-encapsulation of paclitaxel and photosensitizers. The light-generated singlet oxygen from the photosensitizers induce the degradation of the RPMs and the burst release of paclitaxel. Acknowledgement: Basic Science Research Program (NRF-2013R1A1A1009626). |
| 저자 |
Geok Leng Seah, 남윤성
|
| 소속 |
KAIST |
| 키워드 |
ROS; mPEG-b-PPADT; light; anticancer
|
| E-Mail |
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