| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Preparation of Thermo-responsive Polyester Hydrogels for Sustained Protein Drug Delivery |
| 초록 |
The thermo-responsive polymers are usually made of amphiphilic block copolymers. many amphiphilic polymers have been used for the thermo-responsive hydrogels. In this work, we synthesized methoxy poly(ethylene glycol)-co-polyester diblock copolymers composed of ε-caprolactone (CL), L-lactide (LA) and ρ-dioxane (DO) monomers. Molecular weight and molar fraction were analyzed by 1H-NMR spectra. The phase transitions of hydrogels were observed by viscometer. The solutions of polyesters were applied for injectable drug delivery system. They are mixed with Fluorescein isothiocyanate-labeled bovine serum albumin (BSA-FITC) and bovine-insulin, respectively. Small amounts of LA and DO changes physical properties. The solutions of the copolymers show gelation at around 37.5℃. Also, we confirmed that sustained release of BSA-FITC and bovine-insulin through the release profiles. Therefore, polyester hydrogels have possibility of injectable hydrogel systems and sustained release of drugs. |
| 저자 |
박승훈1, 김문석1, 권두연1, 박지훈1, 이해방1, 현훈2
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| 소속 |
1아주대, 2전남대 |
| 키워드 |
thermo-responsive; Hydrogel; Polyester; Drug delivery
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| E-Mail |
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