| 학회 | 한국공업화학회 |
| 학술대회 | 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 23권 2호 |
| 발표분야 | 포스터_생체재료 |
| 제목 | Breast cancer therapy using biomaterials combining antibody and photosensitizer |
| 초록 | Specific accumulation by targeting the cancer site is one of the conditions to become an effective anticancer agent. Antibody therapy against breast cancer specific receptor reported to efficiently prevent the development of cancer, but it has limited penetration into cancer tissue. To overcome this limitation, we combined antibody and photosensitizer (APS) to target tumor sites and increase cancer tissue penetration. Under laser irradiation PS produces reactive oxygen species (ROS). ROS are highly reactive and cause cancer cell death. Since ROS damages the extracellular matrix, the effect of tissue penetration also increases. As a result, the strong fluorescence intensity of APS and the specific interaction of cancer receptor ligand were proved. We confirmed the anticancer effects of APS in vivo and in vitro. Drug penetration and efficient APS distribution across cancer tissues are expected to contribute significantly to the development of breast cancer treatment. |
| 저자 | 이태범, 김경섭, 김지영, 김다혜, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | Photodynamic therapy; Antibody therapy |
