| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Cancer treatment and immune induction by combining the release of excessive cation and photodynamic therapy |
| 초록 | Cancer vaccine is a type of treatmentof cancer-specific immune response induction by injecting cancer-specificantigens (CA). But the CA screening procedure is quite time-consuming. So, weprepared an electrostatic combined zinc-organic compound (EZO) covered withphotosensitizer conjugated polysaccharides (PP). EZO releases excess zinccations inducing cell necrosis, and polysaccharides deliver EZOs to tumor siteas a targeting moiety. Cancer cell necrosis induced by zinc cations andphotodynamic therapy promotes maturation and proliferation of cancer-specificimmune cells. This can reduce the time consumption of CA screening, which is adisadvantage of cancer vaccines. PP coating of EZO was confirmed in vitro like DLS. Effective tumor necrosis,apoptosis induction and immune cell maturation, proliferation were confirmed intumor-bearing mice. Furthermore, in EZO-PP treated mice, proliferated immunecells suppress further metastasis to lungs. |
| 저자 | 이현승, 신희준, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | cancer vaccine; photodynamic therapy |
