| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 |
20권 1호 |
| 발표분야 |
(생물공학)시스템/합성생물학과 생체분자공학 최신기술 |
| 제목 |
Biomaterials for the control of stem cell differentiation and cellular reprogramming |
| 초록 |
Stem cell therapeutics have shown great potential for the treatment of incurable diseases, but their therapeutic efficacy needs to be improved by enhancing specific lineage differentiation for efficient tissue regeneration. Direct reprogramming has been highlighted for the generation of tissue-specific cell types, but low efficiency still remains a major challenge. In this presentation, several materials and devices will be introduced to promote neuronal differentiation of stem cells and direct conversion of skin fibroblasts to neuronal lineage cells. In the first part, microfluidic devices and nanoscale patterned substrates for the reconstitution of neural stem cell microenvironments are reported to promote functional neuronal differentiation. In the second part, micro-devices generating external stimulation and brain-specific microenvironment are reported for significantly improving the efficiency of polymer nanoparticle-mediated direct neural conversion. |
| 저자 |
조승우 |
| 소속 |
연세대 |
| 키워드 |
biomaterial; stem cell differentiation; direct reprogramming
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| E-Mail |
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