| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Preparation of chitosan- and fucoidan-based nanoparticles for effective cancer therapy |
| 초록 |
Development of biodegradable nanoparticles(NPs)has gained attention because they can increase the bioavailability of anticancer drugs with low-toxicity.Chitosan(CS)is a chitin-derived natural polymer with high biocompatibility.Fucoidan(F),which is extracted from brown seaweed,is a sulfated polysaccharide with high biocompatibility.Piperlongumine(PL)has the ability to trigger apoptosis through the increase of oxidative stress in a cell.Since oxidative stress in cancer cells is more prone to triggering apoptosis,PL can kill cancer cells more selectively than normal cells.However,PL is difficult to use in the clinic due to hydrophobic.In this study,CS-F-NP effectively encapsulates PL by ionicgelation,greatly increasing water solubility and bioavailability.The PL-CS-F-NPs efficiently killed human prostate cancer cells via apoptosis through a dramatic increase of intracellular ROSin the cells.This study demonstrates that CS-F-NPs arepromising drug carriers for safe and effective PL delivery |
| 저자 |
최대건, Jayachandran Venkatesan, 김윤석, 심민석
|
| 소속 |
인천대 |
| 키워드 |
chitosan; fucoidan; cancer therapy; piperlongumine; nanoparticles
|
| E-Mail |
|
