| 초록 |
Exogenous growth factor (GF) delivery platform of coacervates (Coa), a tertiary complex of multiple types of polycations, heparin, and cargo GFs, has been utilized into tissue regeneration. Coa encompasses the advantage of high biocompatibility, facile preparation, protection of cargo GFs, and sustained GF release. Coacervate-mediated GF delivery facilitated in vivo tissue repair for skull bone and cartilage when embedded in interpenetrating network composite hydrogel. Coa could be also utilized for coating of electrospun fibrous scaffolds as a skin patch and be directly injected into damaged skin tissues for scarless wound healing. Modulating the chemical structure of polycations could enhance physiological stability of Coa and inhibit random aggregation, by PEGylation or by changing the chain length of polycation. Therefore, our polycation-based GF delivery platform in various engineering applications effectively augments both the quantity and quality of regenerated tissues. |
