| 초록 |
Microbubbles are common contrast agent for ultrasound image. Recently, microbubbles have been investigated as a drug carrier for various drugs. However, due to their short half-life and complexity in surface modification for active targeting, using microbubbles in diagnosis and therapy have obstacles to overcome. Exosomes, one of the extracellular vesicles released by most of cells, are emerging biomaterial in various drug delivery system. In this study, we developed exosome-microbubbles to overcome the limitations of current microbubbles. The membrane proteins of exosome are successfully embedded into microbubbles. The results showed that the stability of Exo-MBs has been improved due to the stable exosome membrane. Moreover, Exo-MBs showed high specific cell targeting ability and high intracellular uptake efficiency. In conclusion, we developed novel particle for diagnosis and drug delivery system that enables longer diagnosis and higher cell specific drug. |
