| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
의료용고분자 부문위원회 |
| 제목 |
Monosaccharide-Responsive Release of Insulin from Polymersomes of Polyboroxole Block Copolymers at Neutral pH |
| 초록 |
We synthesized a boroxole-containing styrenic monomer that can be polymerized by the RAFT method. Polystyreneboroxole (PBOx) and its block copolymers with a poly(ethylene glycol) (PEG) as a hydrophilic block displayed binding to monosaccharides in phosphate buffer at neutral pH, as quantified by Wang's competitive binding experiments. By virtue of a controlled radical polymerization, we were able to adjust the degree of polymerization of the PBOx block to yield sugar-responsive block copolymers that self-assembled into a series of nanostructures including polymersomes. Polymersomes of these block copolymers exhibited glucose-responsive disassembly in a neutral pH medium. We demonstrated the possibility of using these polymersomes as glucose-responsive delivery vehicles for insulin in neutral phosphate buffer (pH = 7.4). Encapsulated insulin could be released from the poly-mersomes only in the presence of fructose or glucose under physiologically relevant conditions. |
| 저자 |
김경택 |
| 소속 |
UNIST |
| 키워드 |
Glucose-Responsive Polymers; Self-assembly; Insulin Release
|
| E-Mail |
|
